Scientific and technological achievements which are used in the life become more and more prominent, and gradually change the people live way. In order to meet the needs of society, it is important do scientific achievements better, knowledge transfer should be the focus of the current knowledge management. This paper first clarifies the related concepts of knowledge chain, knowledge transfer, key path, and then shows the basic connotation of knowledge transfer of scientific and technological achievements, analyzes how scientific and technological achievements are transformed, and finally establishes the knowledge transfer path model of scientific and technological achievements. This paper validates the superiority of the model to solve the real problem, and provides the theoretical basis for the determination of the scientific and technological achievements into the key path of the real product, and has certain practical significance.